DEEP LEARNING-DRIVEN IMAGE ENHANCEMENT AND LESION SEGMENTATION FOR IMPROVED DIAGNOSTIC ACCURACY IN NOISY MEDICAL IMAGES

Main Article Content

Johan Winsli G. Felix
Zaripova Mukaddas Djumayozovna
Kamoliddin Rustamov

Abstract

Medical imaging technologies, including Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and ultrasound, play a significant role in disease diagnosis and treatment planning. Therefore, medical images are sometimes affected by noise, low contrast, motion artifacts, and intensity variations that reduce image quality and complicate lesion detection. This study proposes a deep learning-based framework for image enhancement and lesion segmentation to improve diagnostic accuracy in noisy medical images. The proposed framework adopts a convolutional autoencoder-based image enhancement model with a lightweight U-Net segmentation architecture for creating an effective medical image analysis pipeline. The experimental study was conducted using liver CT images from the Liver Tumor Segmentation (LiTS) dataset. In this context, preprocessing operations such as resizing, normalization, lesion-mask extraction, and Gaussian noise simulation have been implemented to generate noisy medical imaging scenarios. The autoencoder improvement module has been designed to suppress noise and reconstruct improved images while preserving significant anatomical structures. The improved images were used for automated lesion segmentation utilizing the U-Net-based framework. Performance evaluation was carried out using Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM), Dice Score, and Intersection over Union (IoU). The PSNR of 24.57 dB and the SSIM of 0.792 indicate that the enhancement framework can reconstruct high-quality images while retaining their structural information. It has been found that the Dice Score and IoU Score of the segmentation framework are 0.134 and 0.072, respectively, under noisy imaging conditions. Comparative analysis revealed that lesion localization and segmentation consistency were enhanced by enhancement-assisted segmentation compared with direct segmentation of noisy images. The study also demonstrated that the cross-modality analysis is adaptable to both MRI-like and ultrasound-like simulated images. The results show that combining image enhancement and lesion segmentation is a promising approach to achieve more reliable and efficient noisy medical image analysis. The proposed framework offers a promising basis for developing future computer-aided diagnostic systems and automated healthcare applications for noisy medical imaging environments.

Downloads

Download data is not yet available.

Article Details

Section

Articles

How to Cite

Winsli G. Felix, J., Mukaddas Djumayozovna, Z., & Rustamov, K. (2026). DEEP LEARNING-DRIVEN IMAGE ENHANCEMENT AND LESION SEGMENTATION FOR IMPROVED DIAGNOSTIC ACCURACY IN NOISY MEDICAL IMAGES. Qubahan Journal of Medical Sciences, 3(1), 18-34. https://doi.org/10.48161/qjms.v3a89

References

1. Alafer, F., Siddiqi, M. H., Khan, M. S., Ahmad, I., Alhujaili, S., Alrowaili, Z., & Alshabibi, A. S. (2024). A comprehensive exploration of the L-UNet approach: Revolutionizing medical image segmentation. IEEE Access, 12, 140769- 140791. https://ieeexplore.ieee.org/iel8/6287639/10380310/10555261.pdf DOI: https://doi.org/10.1109/ACCESS.2024.3413038

2. Al-Ghanimi, H. H., & Al-Ghanimi, A. H. (2025). Deep learning-driven medical image segmentation using generative adversarial networks and conditional neural networks. Ingénierie des Systèmes d'Information, 30(1), 287. https://doi.org/10.18280/isi.300125 DOI: https://doi.org/10.18280/isi.300125

3. Alsubai, S., Ahmad, W., Anjum, M., Dutta, A. K., Shahab, S., & Genale, A. S. (2025). Enhancing Diagnostic Precision: A Distribution-Based Compressed Denoising Scheme using Transfer Learning for Noise Reduction in Medical Imaging. Current Medical Imaging, 21(1), E15734056391923. http://dx.doi.org/10.2174/0115734056391923250827170359 DOI: https://doi.org/10.2174/0115734056391923250827170359

4. Bhutto, J. A., Tian, L., Du, Q., Sun, Z., Yu, L., & Tahir, M. F. (2022). CT and MRI medical image fusion using noise-removal and contrast-enhancement scheme with a convolutional neural network. Entropy, 24(3), 393. https://doi.org/10.3390/e24030393 DOI: https://doi.org/10.3390/e24030393

5. Brunese, M. C., Rocca, A., Santone, A., Cesarelli, M., Brunese, L., & Mercaldo, F. (2025). Explainable and robust deep learning for liver segmentation through U-Net network. Diagnostics, 15(7), 878. https://doi.org/10.3390/diagnostics15070878 DOI: https://doi.org/10.3390/diagnostics15070878

6. Chen, J., Mei, J., Li, X., Lu, Y., Yu, Q., Wei, Q., ... & Zhou, Y. (2024). TransUNet: Rethinking the U-Net architecture design for medical image segmentation through the lens of transformers. Medical Image Analysis, 97, 103280. https://doi.org/10.1016/j.media.2024.103280 DOI: https://doi.org/10.1016/j.media.2024.103280

7. Doshi, R. V., Badhiye, S. S., & Pinjarkar, L. (2025). Deep learning approach for biomedical image classification. Journal of Imaging Informatics in Medicine, 1-30. https://doi.org/10.1007/s10278-025-01590-8 DOI: https://doi.org/10.1007/s10278-025-01590-8

8. Ergin, F., Parlak, I. B., Adel, M., Gül, Ö. M., & Karpouzis, K. (2024). Noise resilience in Dermoscopic Image Segmentation: Comparing Deep learning architectures for enhanced accuracy. Electronics, 13(17), 3414. https://doi.org/10.3390/electronics13173414 DOI: https://doi.org/10.3390/electronics13173414

9. Gao, Y., Jiang, Y., Peng, Y., Yuan, F., Zhang, X., & Wang, J. (2025). Medical image segmentation: A comprehensive review of deep learning-based methods. Tomography, 11(5), 52. https://doi.org/10.3390/tomography11050052 DOI: https://doi.org/10.3390/tomography11050052

10. Ghandour, C., El-Shafai, W., & El-Rabaie, S. (2023). Medical image enhancement algorithms using deep learning-based convolutional neural networks. Journal of Optics, 52(4), 1931-1941. https://doi.org/10.1007/s12596-022-01078-6 DOI: https://doi.org/10.1007/s12596-022-01078-6

11. Goceri, E. (2023). Medical image data augmentation: techniques, comparisons and interpretations. Artificial Intelligence Review, 56(11), 12561-12605. https://doi.org/10.1007/s10462-023-10453-z DOI: https://doi.org/10.1007/s10462-023-10453-z

12. Herath, H. M. S. S., Herath, H. M. K. K. M. B., Madusanka, N., & Lee, B. I. (2025). A systematic review of medical image quality assessment. Journal of Imaging, 11(4), 100. https://doi.org/10.3390/jimaging11040100 DOI: https://doi.org/10.3390/jimaging11040100

13. Huang, J., Xiang, Y., Gan, S., Wu, L., Yan, J., Ye, D., & Zhang, J. (2025). Application of artificial intelligence in medical imaging for tumor diagnosis and treatment: a comprehensive approach. Discover Oncology, 16(1), 1625. https://doi.org/10.1007/s12672-025-03307-3 DOI: https://doi.org/10.1007/s12672-025-03307-3

14. Joseph, J. (2025). Deep learning-driven image-based cancer diagnosis. https://doi.org/10.30574/wjaets.2025.16.2.1311 DOI: https://doi.org/10.30574/wjaets.2025.16.2.1311

15. Kaggle.com (2020). Liver and Liver Tumor Segmentation. https://www.kaggle.com/datasets/andrewmvd/lits-png

16. Kazerouni, A., Aghdam, E. K., Heidari, M., Azad, R., Fayyaz, M., Hacihaliloglu, I., & Merhof, D. (2022). Diffusion models for medical image analysis: A comprehensive survey. arXiv preprint arXiv:2211.07804. https://arxiv.org/pdf/2211.07804 DOI: https://doi.org/10.1016/j.media.2023.102846

17. Ma, G. (2025). Image key information processing using convolutional neural network and rotation-invariant hierarchical max pooling algorithm. PLoS One, 20(5), e0324504. https://doi.org/10.1371/journal.pone.0324504 DOI: https://doi.org/10.1371/journal.pone.0324504

18. Mahapatra, D., Amrit, P., Singh, O. P., Singh, A. K., & Agrawal, A. K. (2023). Autoencoder-convolutional neural network-based embedding and extraction model for image watermarking. Journal of Electronic Imaging, 32(2), 021604-021604. https://www.researchgate.net/profile/Om-Singh-3/publication/363686202_Autoencoder-convolutional_neural_network-based_embedding_and_extraction_model_for_image_watermarking/links/632c4575873eca0c00a8f40c/Autoencoder-convolutional-neural-network-based-embedding-and-extraction-model-for-image-watermarking.pdf

19. Mashmool, A., Delzanno, G., Saadatfar, H., Ahmad, A., Koschke, R., Alizadehsani, R., ... & D'Agostino, D. (2026). Edge Computing in Healthcare Using Machine Learning: A Systematic Literature Review. Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, 16(1), e70069. https://doi.org/10.1002/widm.70069 DOI: https://doi.org/10.1002/widm.70069

20. Mudeng, V., Kim, M., & Choe, S. W. (2022). Prospects of structural similarity index for medical image analysis. Applied Sciences, 12(8), 3754. https://doi.org/10.3390/app12083754 DOI: https://doi.org/10.3390/app12083754

21. Neto, C., Hak, F., Ferreira, D., Abelha, A., & Machado, J. (2025). Automation of hospital workflows using international standards: A case study with imaging exams. Computer Methods and Programs in Biomedicine, 266, 108777. https://doi.org/10.1016/j.cmpb.2025.108777 DOI: https://doi.org/10.1016/j.cmpb.2025.108777

22. Obuchowicz, R., Strzelecki, M., & Piórkowski, A. (2024). Clinical applications of artificial intelligence in medical imaging and image processing—A review. Cancers, 16(10), 1870. https://doi.org/10.3390/cancers16101870 DOI: https://doi.org/10.3390/cancers16101870

23. Pan, S., Liu, X., Xie, N., & Chong, Y. (2023). EG-TransUNet: a transformer-based U-Net with enhanced and guided models for biomedical image segmentation. BMC bioinformatics, 24(1), 85. https://doi.org/10.1186/s12859-023-05196-1 DOI: https://doi.org/10.1186/s12859-023-05196-1

24. Rasool, N., & Bhat, J. I. (2023). Unveiling the complexity of medical imaging through deep learning approaches. Chaos Theory and Applications, 5(4), 267-280. https://doi.org/10.51537/chaos.1326790 DOI: https://doi.org/10.51537/chaos.1326790

25. Rema, P., Moorthy, S., Bright, B., & BR, M. (2026). An Attention-Guided Residual 3D U-Net with Focal Tversky-Dice Loss for Multi-Modal Pancreatic Tumor Segmentation Using Synthetic Volumetric Imaging. Cancer Treatment and Research Communications, 101146. https://doi.org/10.1016/j.ctarc.2026.101146 DOI: https://doi.org/10.1016/j.ctarc.2026.101146

26. Sahu, A., Mathur, S., Takaoka, H., Ota, J., Meinel, F. G., Böttcher, B., ... & Jensen, C. T. (2025). Transforming CT imaging with deep learning: Noise reduction, artifact management, and clinical applications — A comprehensive review. European Journal of Radiology Artificial Intelligence, 100042. https://doi.org/10.1016/j.ejrai.2025.100042 DOI: https://doi.org/10.1016/j.ejrai.2025.100042

27. Salem, M. A., Kasem, H. M., Abdelfatah, R. I., El-Ganiny, M. Y., & Roshdy, R. A. (2025). A KLJN-based thermal noise modulation scheme with enhanced reliability for low-power IoT communication. IEEE Open Journal of the Communications Society. Digital Object Identifier 10.1109/OJCOMS.2025.3595087 DOI: https://doi.org/10.1109/OJCOMS.2025.3595087

28. Shi, J., Guo, C., & Wu, J. (2022). A hybrid robust-learning architecture for medical image segmentation with noisy labels. Future Internet, 14(2), 41. https://doi.org/10.3390/fi14020041 DOI: https://doi.org/10.3390/fi14020041

29. Solano-Cordero, C. M., Encina-Baranda, N., Pérez-Liva, M., & Herraiz, J. L. (2025). Recent Advances in B-Mode Ultrasound Simulators. Applied Sciences, 15(23), 12535. https://doi.org/10.3390/app152312535 DOI: https://doi.org/10.3390/app152312535

30. Soleimani, P., & Farezi, N. (2023). Utilizing deep learning via the 3D UU-Netneural network for the delineation of brain stroke lesions in MRI iimages Scientific Reports, 13(1), 19808. https://doi.org/10.1038/s41598-023-47107-7 DOI: https://doi.org/10.1038/s41598-023-47107-7

31. Sun, H., Zhou, W., Yang, J., Shao, Y., Xing, L., Zhao, Q., & Zhang, L. (2024). An improved medical image classification algorithm based on the Adam optimizer. Mathematics, 12(16), 2509. https://doi.org/10.3390/math12162509 DOI: https://doi.org/10.3390/math12162509

32. Sundarrajan, M., Choudhry, M. D., Biju, J., Krishnakumar, S., & Rajeshkumar, K. (2024). Enhancing low-light medical imaging through deep learning-based noise reduction techniques. Indian Journal of Science and Technology, 17(34), 3567-3579. https://doi.org/10.17485/IJST/v17i34.2489 DOI: https://doi.org/10.17485/IJST/v17i34.2489

33. Xie, J., Zhou, J., Yang, M., Xu, L., Li, T., Jia, H., ... & Liu, M. (2025). Lesion segmentation method for multiple types of liver cancer based on balanced dice loss. Medical Physics, 52(5), 3059-3074. DOI:10.1002/mp.17624 DOI: https://doi.org/10.1002/mp.17624

34. Xu, Y., Quan, R., Xu, W., Huang, Y., Chen, X., & Liu, F. (2024). Advances in medical image segmentation: A comprehensive review of traditional, deep learning, and hybrid approaches. Bioengineering, 11(10), 1034. https://doi.org/10.3390/bioengineering11101034 DOI: https://doi.org/10.3390/bioengineering11101034

35. Yojana, K., & Rani, L. T. (2023). OCT layer segmentation using U-NET semantic segmentation and RESNET34 encoder-decoder. Measurement: Sensors, 29, 100817. https://doi.org/10.1016/j.measen.2023.100817 DOI: https://doi.org/10.1016/j.measen.2023.100817

36. Yousef, R., Khan, S., Gupta, G., Siddiqui, T., Albahlal, B. M., Alajlan, S. A., & Haq, M. A. (2023). U-Net-based models towards optimal MR brain image segmentation. Diagnostics, 13(9), 1624. https://doi.org/10.3390/diagnostics13091624 DOI: https://doi.org/10.3390/diagnostics13091624

37. Zhang, C., Deng, X., & Ling, S. H. (2024). Next-gen medical imaging: U-Net evolution and the rise of transformers. Sensors, 24(14), 4668. https://doi.org/10.3390/s24144668 DOI: https://doi.org/10.3390/s24144668

38. Zhang, Y. (2025). Application of Image Segmentation Technology Based on Machine Learning in Medical Image Analysis. In ITM Web of Conferences (Vol. 73, p. 02034). EDP Sciences. https://doi.org/10.1051/itmconf/20257302034 DOI: https://doi.org/10.1051/itmconf/20257302034

Similar Articles

You may also start an advanced similarity search for this article.