EXPLAINABLE AI-BASED MULTI-SCALE FEATURE FUSION FOR ACCURATE TUMOUR DETECTION AND CLASSIFICATION IN RADIOLOGICAL IMAGES
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Abstract
Detection and classification of brain tumors are essential in medical imaging, as early and accurate diagnosis aids in treatment planning and patient outcomes. Magnetic Resonance Imaging (MRI) is a common imaging technique used in medicine, especially for brain imaging. Magnetic Resonance Imaging (MRI) is a medical imaging technique used for brain scanning, which is time-consuming and traditionally highly dependent on expert interpretation. While many AI models have been developed for the automatic detection of tumors, recent achievements in Artificial Intelligence (AI) and deep learning have shown great potential; however, many available models lack interpretability and fail to leverage the multi-level features of images. For this reason, this study presents an Explainable AI (XAI) framework for accurate brain Tumor detection and classification using MRI images. The study employed the Brain Tumor MRI Dataset, which contains 7,200 MRI images belonging to four classes (Glioma, Meningioma, Pituitary tumor, and No tumor). To enhance the model's performance, the images underwent preprocessing techniques such as resizing, normalization, and data augmentation. A basic CNN model and a CNN with High-Quality Gradient Class Activation Maps (CNN-XAI) were developed, both using batch normalization, dropout, Early Stopping, and ReduceLROnPlateau. Four metrics, accuracy, precision, recall, and F1-score, along with ROC-AUC analysis, a confusion matrix, and an interpretability assessment, were used to evaluate performance. The experimental results showed that the CNN baseline model achieved the highest classification accuracy of 87.44%, with Precision, Recall, and F1-score values of 88.69%, 87.44%, and 87.13%, respectively. The proposed CNN-XAI framework achieved 82% accuracy and improved transparency and interpretability by localizing the tumor with Grad-CAM. Both models demonstrated good discriminative ability, with near-perfect performance for the pituitary and non-tumor classes in ROC-AUC analysis. Glioma tumors continued to be the most challenging category owing to their imaging heterogeneity. These results suggest that CNN-based deep learning models contribute to automated brain tumor classification, and that explainable AI techniques provide a stronger understanding of and trust in the clinical application of these models. The proposed framework demonstrates the potential of combining deep learning and explainability for reliable, interpretable AI-assisted diagnosis in radiological imaging systems.
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1. Abdullaeva, U., Pape, B., & Hirvonen, J. (2024). Diagnostic accuracy of MRI in detecting the perineural spread of head and neck tumors: a systematic review and meta-analysis. Diagnostics, 14(1), 113. https://doi.org/10.3390/diagnostics14010113 DOI: https://doi.org/10.3390/diagnostics14010113
2. Abrantes, J., & Pouria Rouzrokh. (2024). Explaining explainability: The role of XAI in medical imaging. European Journal of Radiology, 173, 111389–111389. https://doi.org/10.1016/j.ejrad.2024.111389 DOI: https://doi.org/10.1016/j.ejrad.2024.111389
3. Abueed, O., Wang, Y., & Khasawneh, M. (2025). A Systematic Review of U‐Net Optimizations: Advancing Tumor Segmentation in Medical Imaging. IET Image Processing, 19(1), e70203. https://doi.org/10.1049/ipr2.70203 DOI: https://doi.org/10.1049/ipr2.70203
4. Ali, A., Alghamdi, M., Marzuki, S. S., Tengku Din, T. A. D. A. A., Yamin, M. S., Alrashidi, M., ... & Ahmed, N. (2025). Exploring AI approaches for breast cancer detection and diagnosis: A review Article. Breast Cancer: Targets and Therapy, 927-947. https://doi.org/10.2147/BCTT.S550307 DOI: https://doi.org/10.2147/BCTT.S550307
5. Alksas, A., Shehata, M., Saleh, G. A., Shaffie, A., Soliman, A., Ghazal, M., ... & El-Baz, A. (2021). A novel computer-aided diagnostic system for accurate detection and grading of liver tumors. Scientific reports, 11(1), 13148. https://doi.org/10.1038/s41598-021-916340 DOI: https://doi.org/10.1038/s41598-021-91634-0
6. Anari, S., Sadeghi, S., Sheikhi, G., Ranjbarzadeh, R., & Bendechache, M. (2025). Explainable attention-based breast tumor segmentation using a combination of UNet, ResNet, DenseNet, and EfficientNet models. Scientific Reports, 15(1), 1027. https://doi.org/10.1038/s41598-024-84504-y DOI: https://doi.org/10.1038/s41598-024-84504-y
7. Arora, V., Sidhu, B. S., & Singh, K. (2022). Comparison of computed tomography and magnetic resonance imaging in evaluation of skull lesions. Egyptian Journal of Radiology and Nuclear Medicine, 53(1), 67. https://doi.org/10.1186/s43055-022-00745-9 DOI: https://doi.org/10.1186/s43055-022-00745-9
8. Baker, M. R., Padmaja, D. L., Puviarasi, R., Mann, S., Panduro-Ramirez, J., Tiwari, M., & Samori, I. A. (2022). Implementing Critical Machine Learning (ML) Approaches for Generating Robust Discriminative Neuroimaging Representations Using Structural Equation Model (SEM). Computational and Mathematical Methods in Medicine, 2022, 1–12. https://doi.org/10.1155/2022/6501975
9. Biswas, S., Mostafiz, R., Uddin, M. S., & Paul, B. K. (2024). XAI-FusionNet: Diabetic foot ulcer detection based on multi-scale feature fusion with explainable artificial intelligence. Heliyon, 10(10), e31228. https://doi.org/10.1016/j.heliyon.2024.e31228 DOI: https://doi.org/10.1016/j.heliyon.2024.e31228
10. Ennab, M., & Mcheick, H. (2025). Advancing AI Interpretability in Medical Imaging: A Comparative Analysis of Pixel-Level Interpretability and Grad-CAM Models. Machine Learning and Knowledge Extraction, 7(1), 12. https://doi.org/10.3390/make7010012 DOI: https://doi.org/10.3390/make7010012
11. GHARAIBEH, N. (2025). Enhancing interpretability in brain tumor detection: Leveraging Grad-CAM and SHAP for explainable AI in MRI-based cancer diagnosis. Applied Computer Science, 21(3), 182-197. https://ph.pollub.pl/index.php/acs/article/download/7375/5202 DOI: https://doi.org/10.35784/acs_7375
12. Huo, X., Sun, G., Tian, S., Wang, Y., Yu, L., Long, J., ... & Li, A. (2024). HiFuse: Hierarchical multi-scale feature fusion network for medical image classification. Biomedical signal processing and control, 87, 105534. https://arxiv.org/pdf/2209.10218 DOI: https://doi.org/10.1016/j.bspc.2023.105534
13. Iqbal, S., N. Qureshi, A., Li, J., & Mahmood, T. (2023). On the Analysis of Medical Images Using Traditional Machine Learning Techniques and Convolutional Neural Networks. Archives of Computational Methods in Engineering, 30. https://doi.org/10.1007/s11831-023-09899-9 DOI: https://doi.org/10.1007/s11831-023-09899-9
14. Kaggle.com (2021). Brain Tumor MRI Dataset. https://www.kaggle.com/datasets/masoudnickparvar/brain-tumor-mri-dataset
15. Li, Z., Li, D., Xu, C., Wang, W., Hong, Q., Li, Q., & Tian, J. (2022, September). Tfcns: A cnn-transformer hybrid network for medical image segmentation. In International Conference on Artificial Neural Networks (pp. 781-792). Cham: Springer Nature Switzerland. https://arxiv.org/pdf/2207.03450 DOI: https://doi.org/10.1007/978-3-031-15937-4_65
16. Lother, D., Robert, M., Elwood, E., Smith, S. M., Tunariu, N., Johnston, S., … Sharma, B. (2023). Imaging in metastatic breast cancer, CT, PET/CT, MRI, WB-DWI, CCA: review and new perspectives. Cancer Imaging, 23(1). https://doi.org/10.1186/s40644-023-00557-8 DOI: https://doi.org/10.1186/s40644-023-00557-8
17. Mosquera, C., Ferrer, L., Milone, D. H., Luna, D., & Ferrante, E. (2024). Class imbalance in medical image classification: towards better evaluation practices for discrimination and calibration performance. European Radiology, 34(12), 7895-7903. DOI: https://doi.org/10.1007/s00330-024-10834-0
18. Nirob, M. A. S., Bishshash, P., Khatun, T., Sharmin, S., Hasan, M. Z., & Arefin, M. S. (2025, February). Attention-based multi-scale fusion for brain tumor classification with explainable AI. In 2025 International Conference on Electrical, Computer and Communication Engineering (ECCE) (pp. 1- 6). IEEE. https://www.researchgate.net/profile/Md-Nirob/publication/392221177_Attention-Based_Multi-Scale_Fusion_for_Brain_Tumor_Classification_with_Explainable_AI/links/683aeab1c33afe388ac94446/Attention-Based-Multi-Scale-Fusion-for-Brain-Tumor-Classification-with-Explainable-AI.pdf DOI: https://doi.org/10.1109/ECCE64574.2025.11014033
19. Raposo, H. (2024). Intelligent imaging: A systematic review of artificial intelligence techniques in disease detection, segmentation, and classification. Segmentation, and Classification (May 13, 2024). https://papers.ssrn.com/sol3/Delivery.cfm?abstractid=5342645 DOI: https://doi.org/10.2139/ssrn.5342645
20. Shaker, A. M., & Xiong, S. (2023). Lung Image Classification Based on Long Short-Term Memory Recurrent Neural Network. Journal of Physics: Conference Series, 2467(1), 012007. https://doi.org/10.1088/1742-6596/2467/1/012007 DOI: https://doi.org/10.1088/1742-6596/2467/1/012007
21. Suganyadevi, S., Seethalakshmi, V., & Balasamy, K. (2021). A review on deep learning in medical image analysis. International Journal of Multimedia Information Retrieval, 11(1), 19–38. https://doi.org/10.1007/s13735-021-00218-1 DOI: https://doi.org/10.1007/s13735-021-00218-1
22. Vilone, G., & Longo, L. (2021). A Quantitative Evaluation of Global, Rule-Based Explanations of Post-Hoc, Model-Agnostic Methods. Frontiers in Artificial Intelligence, 4. https://doi.org/10.3389/frai.2021.717899 DOI: https://doi.org/10.3389/frai.2021.717899
23. Wang, S., Mao, N., Duan, S., Li, Q., Li, R., Jiang, T., ... & Gu, Y. (2021). Radiomic analysis of contrast-enhanced mammography with different image types: classification of breast lesions. Frontiers in Oncology, 11, 600546. https://doi.org/10.3389/fonc.2021.600546 DOI: https://doi.org/10.3389/fonc.2021.600546
24. World Health Organization. (2025, February 3). Cancer. Retrieved from the World Health Organization website: https://www.who.int/news-room/fact-sheets/detail/cancer
25. Xi, X., Li, W., Li, B., Li, D., Tian, C., & Zhang, G. (2022). Modality-correlation embedding model for breast tumor diagnosis with mammography and ultrasound images. Computers in Biology and Medicine, 150, 106130. https://www.sciencedirect.com/science/article/am/pii/S0010482522008381 DOI: https://doi.org/10.1016/j.compbiomed.2022.106130
26. Yaqub, M., Jinchao, F., Ahmed, S., Mehmood, A., Chuhan, I. S., Manan, M. A., & Pathan, M. S. (2023). DeepLabV3, IBCO-based ALCResNet: A fully automated classification and grading system for brain tumors. Alexandria Engineering Journal, 76, 609-627. https://doi.org/10.1016/j.aej.2023.06.062 DOI: https://doi.org/10.1016/j.aej.2023.06.062
27. Yu, S., & Zhou, P. (2025). An optimized transformer model for efficient detection of thoracic diseases in chest X-rays with multi-scale feature fusion. PLOS One, 20(5), e0323239. https://doi.org/10.1371/journal.pone.0323239 DOI: https://doi.org/10.1371/journal.pone.0323239
28. Zaitoon, R., Mohanty, S. N., Godavarthi, D., & Ramesh, J. V. N. (2024). SPBTGNS: Design an efficient model for survival prediction in brain tumor patients using a generative adversarial network with neural architecture search operations. IEEE Access, 12, 140847-140869. Digital Object Identifier 10.1109/ACCESS.2024.3430074 DOI: https://doi.org/10.1109/ACCESS.2024.3430074